In Vivo Toxicity Study on The Effects of Aqueous Propolis Extract From Malaysian Stingless Bee (Geniotrigona thoracica) in Mice

Geniotrigona thoracica is a stingless bee species of Trigona genus. Propolis resinous natural product obtained from honeybees hive with geographical and floral specifications or exudate as such by-products resulting variety botanical processes. Despite its long use for health conditions, the toxicity profile propolis sourced Malaysian bees has not been sufficiently evaluated. For in vivo assessment, acute oral on effects aqueous extracts (APE) was examined. Male mice swiss strain, were subjected to testing 14 days. The APE at doses 400, 1000 2000 mg/kg body weight supplemented daily through gavage. clinical signs general behaviour, weight, relative organ histopathology changes investigated. In study focused group consisting 4 groups including Normal (NS), 400 (APE 400), 1000) dan 2000). Regarding profile, it proposed that supplementation did induce any mortality no visible toxicity. No significant recorded. All internal organs macroscopically healthy gross lesion. Likewise, histopathological examinations kidney showed mild moderate histological lesions. Interestingly, lesion adverse an increased dosage extract supplementation. This considerable anti-inflammatory activities. It also demonstrated relatively safe be consumed orally dose weight.